The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 19, 2021
Filed:
Jul. 10, 2015
Applicants:
Onur Boyman, Küsnacht, CH;
Natalia Arenas-ramirez, Zürich, CH;
Chao Zou, Basel, CH;
Inventors:
Assignee:
Universität Zürich, Zürich, CH;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/20 (2006.01); A61K 39/395 (2006.01); A61K 39/00 (2006.01); C07K 14/55 (2006.01); C07K 16/24 (2006.01);
U.S. Cl.
CPC ...
C07K 16/246 (2013.01); A61K 38/2013 (2013.01); A61K 39/3955 (2013.01); C07K 14/55 (2013.01); A61K 2039/505 (2013.01); C07K 2317/34 (2013.01); C07K 2317/55 (2013.01); C07K 2317/565 (2013.01); C07K 2317/74 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01);
Abstract
The invention relates to a human Interleukin-2 (hIL-2) specific monoclonal antibody (mAb), or antigen binding fragment thereof, the binding of which to hIL-2 inhibits binding of hIL-2 to CD25 and the antibody is characterized by any of the parameters: the variable chain of the mAb comprises the amino acid sequence of SEQ ID NO 005 or SEQ ID NO 006; the binding to hIL-2 is characterized by a dissociation constant (K)≤7.5 nmol/L; the binding to hIL-2 is characterized by an off-rate (K)≤1×10sand/or the antibody displays no measurable cross-reactivity to murine IL-2.