The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 19, 2021
Filed:
Apr. 22, 2016
Carnegie Mellon University, Pittsburgh, PA (US);
University of Pittsburgh—of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
O. Burak Ozdoganlar, Sewickley, PA (US);
Marcel P. Bruchez, Edgewood, PA (US);
Phil G. Campbell, Pittsburgh, PA (US);
Jonathan W. Jarvik, Pittsburgh, PA (US);
Louis Falo, Wexford, PA (US);
Geza Erdos, Wexford, PA (US);
Carnegie Mellon University, Pittsburgh, PA (US);
University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
Abstract
Provided herein are devices and methods used to produce tattoo biosensors that are based on spatially controlled intracutaneous gene delivery of optical reporters driven by specific transcription factor pathways for a given cytokine or other analyte. The biosensors can be specific to a given analyte, or more generically represent the convergence of several cytokines into commonly shared intracellular transcription factor pathways. These biosensors can be delivered as an array in order to monitor multiple cytokines. Biosensor redeployment can enable chronic monitoring from months to years. The tattooed biosensor array of the present invention includes endogenous reporter cells, naturally tuned to each patient's own biology and can be used to reliably measure the state of a patient in real-time.