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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10894058 B1

PDFFull Text
Date of Patent:
Jan. 19, 2021

Filed:

Aug. 19, 2015

Method for producing solid dispersion containing hardly soluble polyphenol

Applicant:

Kao Corporation, Tokyo, JP;

Inventors:

Masahiro Umehara, Sumida-ku, JP;

Akihiro Uda, Edogawa-ku, JP;

Tetsuya Abe, Edogawa-ku, JP;

Yasushi Yamada, Narita, JP;

Assignee:

KAO CORPORATION, Tokyo, JP;

Attorney:

Birch, Stewart, Kolasch & Birch, LLP

Primary Examiner:

Rei Tsang Shiao

Int. Cl.
CPC ...
A61K 31/7048 (2006.01); A61K 8/73 (2006.01); A61Q 19/02 (2006.01); A61K 8/49 (2006.01); A61Q 15/00 (2006.01); A61Q 7/00 (2006.01); A61Q 19/10 (2006.01); A61Q 17/04 (2006.01); A61Q 5/02 (2006.01); A61K 8/60 (2006.01); A61K 47/26 (2006.01); A61K 47/36 (2006.01); A61K 31/732 (2006.01); B01F 3/22 (2006.01); A61K 9/14 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7048 (2013.01); A61K 8/498 (2013.01); A61K 8/60 (2013.01); A61K 8/73 (2013.01); A61K 31/732 (2013.01); A61K 47/26 (2013.01); A61K 47/36 (2013.01); A61Q 5/02 (2013.01); A61Q 7/00 (2013.01); A61Q 15/00 (2013.01); A61Q 17/04 (2013.01); A61Q 19/02 (2013.01); A61Q 19/10 (2013.01); B01F 3/2284 (2013.01); A61K 9/146 (2013.01);
Abstract

Provided is a method of producing a solid dispersion that can improve solubility of a hardly soluble polyphenol in water. Specifically, provided is a method of producing a solid dispersion containing an amorphous hardly soluble polyphenol, the method including the steps of: mixing (A) a hardly soluble polyphenol, (B) at least one selected from the group consisting of a plant-derived polysaccharide, a seaweed-derived polysaccharide, and a microorganism-derived polysaccharide, a plant-derived polypeptide, and a microorganism-derived polypeptide, and (C) at least one selected from the group consisting of a monosaccharide and a disaccharide, followed by melting of the mixture by heating; and solidifying the molten product by cooling.

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