The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 12, 2021
Filed:
Aug. 31, 2017
Isi Life Sciences, Inc., Newport Beach, CA (US);
John Fante, Newport Beach, CA (US);
Theodore Hessler, III, Newport Beach, CA (US);
Robert M. Moriarty, Michiana Shores, MI (US);
Richard Pariza, Chicago, IL (US);
Gerald F. Swiss, San Diego, CA (US);
David White, Newport Beach, CA (US);
Craig Keshishian, Newport Beach, CA (US);
ISI Life Sciences, Inc., Newport Beach, CA (US);
Abstract
This invention is directed to methods for the facile and accurate identification of cancer cells in a tissue sample, such as a surgical field. In particular, the compositions and methods employ conjugates comprising pro-fluorescent fluorescein based moieties bound to folic or pteroic acid targeting moiety optionally through a linker. The pro-fluorescent fluorescein based moieties are non-fluorescent but capable of being rendered fluorescent by intracellular processes. The conjugates are employed to detect cancer cells that overexpress folic acid receptors thereby providing for differential accumulation of these conjugates in these cells.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile