The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 12, 2021
Filed:
Sep. 18, 2017
Applicants:
Duke University, Durham, NC (US);
Ohio State Innovation Foundation, Columbus, OH (US);
Inventors:
Shahid M. Nimjee, Columbus, OH (US);
George A. Pitoc, Durham, NC (US);
Juliana Layzer, Durham, NC (US);
Bruce Sullenger, Durham, NC (US);
Assignees:
DUKE UNIVERSITY, Durham, NC (US);
OHIO STATE INNOVATION FOUNDATION, Columbus, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07H 21/04 (2006.01); C12N 15/113 (2010.01); C12N 15/115 (2010.01); A61K 31/7115 (2006.01); A61K 47/64 (2017.01); A61K 45/06 (2006.01); A61K 47/60 (2017.01); A61K 31/7105 (2006.01); A61K 47/54 (2017.01); A61P 7/02 (2006.01); A61K 31/7088 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 31/7088 (2013.01); A61K 31/7105 (2013.01); A61K 31/7115 (2013.01); A61K 45/06 (2013.01); A61K 47/554 (2017.08); A61K 47/60 (2017.08); A61K 47/64 (2017.08); A61P 7/02 (2018.01); C12N 15/115 (2013.01); C12N 2310/113 (2013.01); C12N 2310/16 (2013.01); C12N 2310/317 (2013.01); C12N 2310/3183 (2013.01); C12N 2310/3515 (2013.01);
Abstract
Provided herein are aptamers capable of inhibiting the activity of Von Willebrand Factor (VWF). Pharmaceutical compositions comprising these aptamers are also provided. Methods of preventing blood clot formation in a subject by administering the aptamers are provided and methods of treating a blood clot by administering a VWF-targeting agent are also provided.