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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10889800 B1

PDFFull Text
Date of Patent:
Jan. 12, 2021

Filed:

May. 25, 2018

Method and composition for generating basal forebrain cholinergic neurons (bfcns)

Applicants:

New York Stem Cell Foundation, Inc., New York, NY (US);

Icahn School of Medicine AT Mount Sinai, New York, NY (US);

Inventors:

Scott Noggle, New York, NY (US);

Maitane Ortiz-Virumbrales, New York, NY (US);

Sam Gandy, New York, NY (US);

Ilya Kruglikov, New York, NY (US);

Michelle Ehrlich, New York, NY (US);

Assignees:

New York Stem Cell Foundation, Inc., New York, NY (US);

Icahn School of Medicine at Mount Sinai, New York, NY (US);

Attorney:

DLA Piper LLP (US)

Primary Examiner:

Kimberly Ballard

Assistant Examiner:

Stacey N MacFarlane

Int. Cl.
CPC ...
A61K 35/30 (2015.01); C12N 5/0793 (2010.01); C12N 15/11 (2006.01); C12N 9/22 (2006.01); G01N 33/50 (2006.01); C12N 5/074 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0619 (2013.01); A61K 35/30 (2013.01); C12N 5/0696 (2013.01); C12N 9/22 (2013.01); C12N 15/11 (2013.01); G01N 33/5058 (2013.01); C12N 2310/20 (2017.05); C12N 2501/15 (2013.01); C12N 2501/41 (2013.01); C12N 2501/999 (2013.01); C12N 2506/02 (2013.01); C12N 2506/45 (2013.01); C12N 2510/00 (2013.01); C12N 2800/80 (2013.01); G01N 2800/2814 (2013.01);
Abstract

The invention relates to methods and compositions for developing basal forebrain cholinergic neurons (BFCNs) from stem cells, and in particular, BFCNs having repaired electrophysiological defects relating to one or more mutations in PSEN2, and to the use of such BFCNs in cell-based therapies to treat Alzheimer's disease.

Find Patent Forward Citations

Noggle, Scott. (2021). Method and composition for generating basal forebrain cholinergic neurons (bfcns) (U.S. Patent No. 10889800). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10889800

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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