The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10889562 B1

PDF
Full Text
Expired
Date of Patent:
Jan. 12, 2021

Filed:

Aug. 12, 2020
Applicant:

Rigel Pharmaceuticals, Inc., South San Francisco, CA (US);

Inventors:

Jiaxin Yu, Foster City, CA (US);

Beth Fernandez, Pacifica, CA (US);

Gary Park, Moss Beach, CA (US);

Ihab Darwish, San Carlos, CA (US);

Assignee:

Rigel Pharmaceuticals, Inc., South San Francisco, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/04 (2006.01); C07D 257/04 (2006.01); C07C 323/60 (2006.01); C07D 249/12 (2006.01); A61P 37/02 (2006.01);
U.S. Cl.
CPC ...
C07D 401/04 (2013.01); A61P 37/02 (2018.01); C07C 323/60 (2013.01); C07D 249/12 (2013.01); C07D 257/04 (2013.01);
Abstract

Aspects of the present disclosure include prodrugs of compounds that activate Nrf2. Such prodrugs find use in the treatment of autoimmune and inflammatory diseases and disorders, such as for example psoriasis and multiple sclerosis. Embodiments of the present disclosure also relate to pharmaceutical compositions that include these prodrugs, methods of using these prodrugs in the treatment of various diseases and disorders, processes for preparing these prodrugs and intermediates useful in these processes.


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