The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 12, 2021
Filed:
Sep. 18, 2015
Applicant:
Massachusetts Institute of Technology, Cambridge, MA (US);
Inventors:
Sung Hee Ko, Malden, MA (US);
Jongyoon Han, Bedford, MA (US);
Assignee:
Massachusetts Institute of Technology, Cambridge, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); G01N 27/447 (2006.01); G01N 30/00 (2006.01);
U.S. Cl.
CPC ...
B01L 3/502753 (2013.01); G01N 27/44791 (2013.01); G01N 30/0005 (2013.01); B01L 2300/0877 (2013.01); B01L 2300/0896 (2013.01); B01L 2400/0415 (2013.01); B01L 2400/086 (2013.01); G01N 2030/001 (2013.01);
Abstract
This disclosure provides an apparatus and a method for quickly, efficiently and continuously fractionating biomolecules, such as DNAs and proteins based on size and other factors, while allowing imaging of the separated biomolecules as they are processed within the apparatus. The apparatus employs angled nanochannels to first preconcentrate and then separate like molecules. Its embodiments offer improved detection sensitivity and separation resolution over existing technologies and multiplexing capabilities.