The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 12, 2021
Filed:
Jun. 26, 2015
Applicant:
GE Healthcare As, Oslo, NO;
Inventors:
Svein Kvale, Oslo, NO;
Ingrid Henriksen, Oslo, NO;
Ole Johannes Tokerud, Oslo, NO;
Per Sontum, Oslo, NO;
Assignee:
GE HEALTHCARE AS, Oslo, NO;
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61L 2/07 (2006.01); A61K 49/22 (2006.01); A61K 47/24 (2006.01); A61K 9/127 (2006.01); A61K 9/107 (2006.01); A61B 8/08 (2006.01);
U.S. Cl.
CPC ...
A61L 2/07 (2013.01); A61K 9/1075 (2013.01); A61K 9/1277 (2013.01); A61K 47/24 (2013.01); A61K 49/22 (2013.01); A61K 49/223 (2013.01); A61B 8/481 (2013.01);
Abstract
The present invention relates to a method for sterilisation of phospholipid suspensions, useful in the preparation of ultrasound contrast agent precursors comprising phospholipid-stabilised perfluorobutane microbubbles. The method provides sterility assurance, without undue thermal degradation of the phospholipid. The method is also amenable to commercial scale manufacture. Also provided are methods of preparing kits and ultrasound contrast agents incorporating the sterilisation method of the invention.