The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10888615 B1

PDF
Full Text
Expired
Date of Patent:
Jan. 12, 2021

Filed:

Apr. 21, 2017
Applicant:

Suzhou Galaxy Biopharma, Co., Ltd., Jiangsu, CN;

Inventors:

Honglin Zhou, Jiangsu, CN;

Jie Liu, Jiangsu, CN;

Xin Dong, Jiangsu, CN;

Bing Sun, Shanghai, CN;

Jiangjun Wang, Shanghai, CN;

Zhiyang Ling, Shanghai, CN;

Chunyan Yi, Shanghai, CN;

Chao Bian, Shanghai, CN;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/42 (2006.01); C07K 16/10 (2006.01); A61P 31/14 (2006.01); C12N 15/63 (2006.01); G01N 33/569 (2006.01); G01N 33/577 (2006.01);
U.S. Cl.
CPC ...
A61K 39/42 (2013.01); A61P 31/14 (2018.01); C07K 16/109 (2013.01); C12N 15/63 (2013.01); G01N 33/56983 (2013.01); G01N 33/577 (2013.01); C07K 2317/21 (2013.01); C07K 2317/33 (2013.01); C07K 2317/76 (2013.01); G01N 2333/186 (2013.01);
Abstract

Provided herein is a human monoclonal antibody 8D6 against hepatitis C virus (HCV) infection. The antibody binds to the E2 subunit of HCV capsid protein, and can prevent HCV from infecting susceptible host cells. By using the antibody variable region gene or the complementary determining region (CDR) gene, different forms of genetic engineering antibodies have been transformed and produced in any expression system of the prokaryotic and eukaryotic cells as therapeutics to prevent or treat HCV infection.


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