The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 05, 2021
Filed:
Dec. 21, 2018
Applicant:
United Kingdom Research and Innovation, Swindon, GB;
Inventors:
Nicolas Phillip James Brindle, Leicester, GB;
Julian Edward Sale, Cambridge, GB;
Assignee:
UNITED KINGDOM RESEARCH AND INNOVATION, Swindon, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/705 (2006.01); C07K 14/71 (2006.01); A61K 38/17 (2006.01); C12N 9/12 (2006.01);
U.S. Cl.
CPC ...
C07K 14/71 (2013.01); C07K 14/70596 (2013.01); C12N 9/12 (2013.01); A61K 38/177 (2013.01); A61K 38/179 (2013.01); C07K 14/705 (2013.01); C12Y 207/10001 (2013.01);
Abstract
In one aspect, provided herein is a polypeptide comprising a modified angiopoietin receptor or fragment thereof, wherein the polypeptide binds preferentially to angiopoietin-2 compared to angiopoeitin-1. Nucleic acid sequences encoding the polypeptide, as well as pharmaceutical uses of the polypeptide in treating diseases such as cancer and inflammation are also provided.