The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 05, 2021

Filed:

Jul. 02, 2019
Applicant:

Genentech, Inc., South San Francisco, CA (US);

Inventors:

Danial Beaudry, South San Francisco, CA (US);

Theresa Cravillion, South San Francisco, CA (US);

Francis Gosselin, South San Francisco, CA (US);

Ngiap-Kie Lim, South San Francisco, CA (US);

Sushant Malhotra, South San Francisco, CA (US);

Qingping Tian, South San Francisco, CA (US);

Haiming Zhang, South San Francisco, CA (US);

Alexander Gmehling, Bad Säckingen, DE;

Alec Fettes, Basel, CH;

Stephan Bachmann, Basel, CH;

Assignee:

Genentech, Inc., South San Francisco, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); B01J 31/24 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); B01J 31/2409 (2013.01); B01J 31/2414 (2013.01); B01J 2231/40 (2013.01); B01J 2531/824 (2013.01); C07B 2200/09 (2013.01);
Abstract

Methods for preparing the Bruton's Tyrosine Kinase ('BTK') inhibitor compound 2-{3'-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4′]bipyridinyl-2′-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided. Methods for preparing tricyclic lactam compounds are also provided.


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