The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 05, 2021

Filed:

Sep. 18, 2014
Applicant:

University of Pittsburgh—of the Commonwealth System of Higher Education, Pittsburgh, PA (US);

Inventors:

Peter Wipf, Pittsburgh, PA (US);

Erin M. Skoda, Columbia, MD (US);

Zhou Wang, Pittsburgh, PA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/495 (2006.01); C07D 295/185 (2006.01); C07D 295/192 (2006.01); A61K 45/06 (2006.01); C07D 295/26 (2006.01); C07D 213/70 (2006.01); C07D 333/16 (2006.01); C07D 261/08 (2006.01); C07D 317/54 (2006.01); C07D 413/12 (2006.01); A61K 31/4525 (2006.01); A61K 31/551 (2006.01); A61K 31/58 (2006.01); A61K 31/496 (2006.01);
U.S. Cl.
CPC ...
C07D 295/192 (2013.01); A61K 31/4525 (2013.01); A61K 31/495 (2013.01); A61K 31/496 (2013.01); A61K 31/551 (2013.01); A61K 31/58 (2013.01); A61K 45/06 (2013.01); C07D 213/70 (2013.01); C07D 261/08 (2013.01); C07D 295/26 (2013.01); C07D 317/54 (2013.01); C07D 333/16 (2013.01); C07D 413/12 (2013.01);
Abstract

A compound, or a pharmaceutically acceptable salt or ester thereof, having a formula I of: R—(Z)—(Y)—(R)—X—R—Rwherein R20 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, or NR, wherein Ris H or alkyl; Ris alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl, alkadienyl, substituted alkadienyl, alkatrienyl, substituted alkatrienyl; X is —C(=0)- or —S(=0)(=0)-; Ris a moiety that includes at least one divalent amino radical; Ris an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group; a is 0 or 1; b is 0 or 1; and c is 0 or 1; provided that if X is —C(=0)- then Y is not S.


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