The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 05, 2021
Filed:
Feb. 19, 2019
Applicant:
Modernatx, Inc., Cambridge, MA (US);
Inventors:
Eric Yi-Chun Huang, Boston, MA (US);
Sze-Wah Tse, Cambridge, MA (US);
Jared Iacovelli, Waltham, MA (US);
Kristine McKinney, Cambridge, MA (US);
Nicholas Valiante, Cambridge, MA (US);
Assignee:
ModernaTX, Inc., Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/39 (2006.01); A61K 9/50 (2006.01); C07K 14/725 (2006.01); A61K 39/00 (2006.01); A61K 9/00 (2006.01); A61K 9/51 (2006.01); A61P 35/00 (2006.01); A61K 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/39 (2013.01); A61K 9/0019 (2013.01); A61K 9/5015 (2013.01); A61K 9/5123 (2013.01); A61K 39/0011 (2013.01); A61K 39/001164 (2018.08); A61P 35/00 (2018.01); C07K 14/7051 (2013.01); A61K 2039/53 (2013.01); A61K 2039/55561 (2013.01); A61K 2039/572 (2013.01); A61K 2039/575 (2013.01);
Abstract
The disclosure features immunomodulatory therapeutic compositions of an mRNA encoding an activating oncogene mutation peptide and an mRNA encoding a polypeptide that enhances immune responses to the activating oncogene mutation peptide, for example an mRNA encoding an immune potentiator. The disclosure also features methods of using the same, for example, to stimulate anti-cancer immune responses.