The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 05, 2021

Filed:

Oct. 18, 2019
Applicant:

Yunbaiyao Zhengwu Science and Technology (Shanghai) Co., Ltd., Shanghai, CN;

Inventors:

Jinghua Zhang, Shanghai, CN;

Zhengwu Shen, Shanghai, CN;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/357 (2006.01); A61K 47/28 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/357 (2013.01); A61K 47/28 (2013.01); A61P 35/00 (2018.01);
Abstract

Described is a dihydroartemisinin-steroid conjugate of formula (I), or a pharmaceutically acceptable salt thereof, where position 10 of dihydroartemisinin is linked to the steroid through a linker X. This application further provides a preparation method of the dihydroartemisinin-steroid conjugate and an application of the dihydroartemisinin-steroid conjugate in the preparation of a drug for treating cancer. The dihydroartemisinin-steroid conjugate of the invention exhibits potent inhibitory activity against various tumor cells and low cytotoxicity, moreover, the conjugate is capable of penetrating the blood-brain barrier, having a broad application prospect.


Find Patent Forward Citations

Zhang, Jinghua. (2021). Dihydroartemisinin-steroid conjugate and preparation method and application thereof (U.S. Patent No. 10881636). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10881636

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