The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 29, 2020

Filed:

Nov. 20, 2017
Applicant:

Los Angeles Biomedical Research Institute AT Harbor-ucla Medical Center, Torrance, CA (US);

Inventors:

Ashraf S. Ibrahim, Torrance, CA (US);

Sameh Soliman, Torrance, CA (US);

John Edwards, Jr., Torrance, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61P 31/10 (2006.01); A61P 35/00 (2006.01); A61K 39/00 (2006.01); A61K 39/39 (2006.01); C07K 16/14 (2006.01); C12Q 1/6895 (2018.01); C07K 14/37 (2006.01); A61P 31/00 (2006.01); G01N 33/569 (2006.01);
U.S. Cl.
CPC ...
G01N 33/56961 (2013.01); A61K 39/0002 (2013.01); A61K 39/0011 (2013.01); A61K 39/39 (2013.01); A61P 31/00 (2018.01); A61P 31/10 (2018.01); A61P 35/00 (2018.01); C07K 14/37 (2013.01); C07K 16/14 (2013.01); C12Q 1/6895 (2013.01); A61K 2039/505 (2013.01); A61K 2039/55505 (2013.01); A61K 2039/585 (2013.01); C07K 2317/76 (2013.01);
Abstract

Presented herein, in certain aspects, are compositions that comprise novel toxin proteins, the nucleic acids that encode them, and/or portions thereof, which toxins are expressed by fungi of the Mucorales order and are thought to contribute to the pathogenesis of Mucormycosis. Also presented herein, in certain aspects, are methods of detecting the presence or absence of novel fungal toxins and/or the nucleic acids that encode them in a sample, which methods can be used to identify the presence of Mucorales in a subject. Methods and/or compositions presented herein can be used to prevent and/or treat a Mucorales infection.


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