The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 29, 2020
Filed:
Apr. 15, 2016
Applicant:
The General Hospital Corporation, Boston, MA (US);
Inventors:
Tilak K. Sundaresan, Jamaica Plain, MA (US);
Zongli Zheng, Hong Kong, CN;
Daniel A. Haber, Chestnut Hill, MA (US);
Shyamala Maheswaran, Lexington, MA (US);
A. John Iafrate, Newton, MA (US);
Assignee:
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); C12N 15/10 (2006.01); C12Q 1/6827 (2018.01);
U.S. Cl.
CPC ...
C12Q 1/6827 (2013.01); C12N 15/1058 (2013.01);
Abstract
Ultra-sensitive assays for the detection of mutations, e.g., from blood-based sources of tumor genetic material (circulating tumor cells or plasma), or other settings in which limiting amounts of DNA, e.g., tumor DNA, is available. The assay is exemplified in the estrogen receptor, but is broadly customizable to target mutations in other genes.