The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 29, 2020

Filed:

Jan. 30, 2020
Applicant:

Ultra Small Fibers, Llc, Wartrace, TN (US);

Inventors:

William Hudson Hofmeister, Nashville, TN (US);

Robert A. Van Wyk, St. Petersburg, FL (US);

Christopher P. Dougherty, Rogers, AR (US);

Collin David Anderson, Chicago, IL (US);

Assignee:

ULTRA SMALL FIBERS, LLC, Wartrace, TN (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61L 27/14 (2006.01); A61L 27/58 (2006.01); C12N 5/0775 (2010.01); A61L 27/22 (2006.01); A61F 2/02 (2006.01); A61L 15/32 (2006.01); A61K 38/39 (2006.01); A61L 15/58 (2006.01); A61L 27/54 (2006.01); A61L 15/22 (2006.01); A61L 15/44 (2006.01); B82Y 5/00 (2011.01); A61F 2/30 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0667 (2013.01); A61F 2/02 (2013.01); A61K 38/39 (2013.01); A61L 15/225 (2013.01); A61L 15/32 (2013.01); A61L 15/44 (2013.01); A61L 15/58 (2013.01); A61L 27/225 (2013.01); A61L 27/54 (2013.01); A61F 2002/30766 (2013.01); A61L 2300/412 (2013.01); B82Y 5/00 (2013.01);
Abstract

A biomimetic lamellar tissue scaffold for tissue regeneration comprises a plurality of lamellae formed of a polymer film and each having a first surface and a second surface. A patterned array of polymer nanofibers protrudes from the first surface of each lamella of the plurality. The lamellae form a plurality of interlamellar spaces between the first and second surfaces of adjacent lamellae. Protuberances formed on the first surface of each lamella maintain the interlamellar spaces. The arrays of polymer nanofibers on the first lamellar surface of each lamella protrude into the interlamellar spaces between adjacent lamellae and are configured to influence the propagation and differentiation of cells populated to or recruited to the scaffold.


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