The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 29, 2020
Filed:
Nov. 28, 2018
Applicants:
Pfizer Inc., New York, NY (US);
The Regents of the University of California, Oakland, CA (US);
Inventors:
Rachel Groth, Walnut Creek, CA (US);
William Brian Snyder, Escondido, CA (US);
Xianjun Cao, San Diego, CA (US);
Robert Joseph Dunn, San Diego, CA (US);
Joseph Dal Porto, Los Gatos, CA (US);
Michael Karin, La Jolla, CA (US);
Assignees:
PFIZER INC., New York, NY (US);
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/24 (2006.01); C07K 16/28 (2006.01); A61P 37/06 (2006.01); A61P 19/02 (2006.01); C12N 15/62 (2006.01); A61K 39/00 (2006.01); C07K 16/40 (2006.01);
U.S. Cl.
CPC ...
C07K 16/24 (2013.01); A61P 19/02 (2018.01); A61P 37/06 (2018.01); C07K 16/2866 (2013.01); C07K 16/40 (2013.01); C12N 15/62 (2013.01); A61K 2039/54 (2013.01); A61K 2039/545 (2013.01); C07K 2317/24 (2013.01); C07K 2317/30 (2013.01); C07K 2317/33 (2013.01); C07K 2317/41 (2013.01); C07K 2317/565 (2013.01); C07K 2317/732 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01);
Abstract
The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to CXCR5. The antibodies can be afucosylated and exhibit increased ADCC compared with the otherwise identical fucosylated antibodies. The invention includes uses, and associated methods of using the antibodies.