The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 29, 2020
Filed:
May. 10, 2019
Argenx Bvba, Zwijnaarde, BE;
Université Catholique DE Louvain, Louvain-la-Neuve, BE;
Sebastian van der Woning, Bachte-Maria-Leerne, BE;
Filip Borgions, Herk-de-Stad, BE;
Torsten Dreier, Sint-Martens-Latem, BE;
Lore Mariën, Ghent, BE;
Gitte De Boeck, Malderen, BE;
Stëphanie Liénart, Wezembeek-Oppem, BE;
Sophie Lucas, Duisburg, BE;
Pierre Coulie, Kraainem, BE;
argenx BVBA, Zwijnaarde, BE;
Université Catholique de Louvain, Louvain-la-Neuve, BE;
Abstract
The present invention relates to antibodies and antigen binding fragments thereof, which bind to a complex of GARP and TGF-β1, particularly a complex of human GARP and human TGF-β1. These antibodies and antigen binding fragments exhibit a combination of advantageous properties including high affinity antigen binding and the ability to inhibit the release of active TGF-β from regulatory T cells. The antibodies and antigen binding fragments of the present invention are relatively resistant to deamidation, isomerization and oxidation, such that they display improved stability.