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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10875876 B1

PDFFull Text
Date of Patent:
Dec. 29, 2020

Filed:

Jun. 28, 2016

Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis b

Applicant:

Janssen Sciences Ireland Uc, Co Cork, IE;

Inventors:

Sandrine Marie Helene Vendeville, Woluwe-Saint-Pierre, BE;

Stefaan Julien Last, Lint, BE;

Samuël Dominique Demin, Antwerpen, BE;

Sandrine Céline Grosse, Beerse, BE;

Geerwin Yvonne Paul Haché, Kapellan, BE;

Lili Hu, Mechelen, BE;

Serge Maria Aloysius Pieters, Hulst, NL;

Geert Rombouts, Barsbeek, BE;

Koen Vandyck, Paal-Beringen, BE;

Wim Gaston Verschueren, Berchem, BE;

Pierre Jean-Marie Bernard Raboisson, Rosieres, BE;

Assignee:

JANSSEN SCIENCES IRELAND UC, County Cork, IE;

Attorney:
Primary Examiner:

Shengjun Wang

Int. Cl.
CPC ...
C07D 267/02 (2006.01); C07D 267/22 (2006.01); C07D 513/00 (2006.01); A61K 31/553 (2006.01); C07D 513/04 (2006.01); C07D 513/20 (2006.01); C07D 515/04 (2006.01); C07D 515/20 (2006.01); C07D 291/08 (2006.01); A61P 31/20 (2006.01); A61K 31/407 (2006.01); A61K 31/542 (2006.01); A61K 31/554 (2006.01); A61K 45/06 (2006.01); C07D 515/10 (2006.01);
U.S. Cl.
CPC ...
C07D 513/04 (2013.01); A61K 31/407 (2013.01); A61K 31/542 (2013.01); A61K 31/554 (2013.01); A61K 45/06 (2013.01); A61P 31/20 (2018.01); C07D 291/08 (2013.01); C07D 513/20 (2013.01); C07D 515/04 (2013.01); C07D 515/10 (2013.01); C07D 515/20 (2013.01);
Abstract

Inhibitors of HBV replication of Formula (I-A) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein Rto R, and Rto Rhave the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.

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