The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 29, 2020
Filed:
Mar. 04, 2016
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Nathanael Gray, Boston, MA (US);
Tinghu Zhang, Brookline, MA (US);
Hai-Tsang Huang, Boston, MA (US);
Yubao Wang, Newton, MA (US);
Jean Zhao, Brookline, MA (US);
Hwan Geun Choi, Seoul, KR;
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Abstract
Provided herein are small molecule inhibitors of maternal embryonic leucine zipper kinase (MELK) having the structure of formula (I), wherein X and R-Rare defined in the specification. The compounds are useful for treating cancer and other conditions or diseases associated with aberrant MELK expression. Also provided herein are pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier. The invention also provides methods of treating cancers associated with over-expression of MELK.