The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 29, 2020
Filed:
Jul. 24, 2017
Applicant:
Virginia Commonwealth University, Richmond, VA (US);
Inventors:
Martin K. Safo, Richmond, VA (US);
Guoyan Xu, Richmond, VA (US);
Yan Zhang, Richmond, VA (US);
Osheiza Abdulmalik, Richmond, VA (US);
Assignees:
Virginia Commonwealth University, Richmond, VA (US);
The Children's Hospital of Philadelphia, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 307/46 (2006.01); A61P 7/00 (2006.01); A61P 43/00 (2006.01); C07F 9/655 (2006.01); C07D 417/04 (2006.01);
U.S. Cl.
CPC ...
C07D 307/46 (2013.01); A61P 7/00 (2018.01); A61P 43/00 (2018.01); C07D 417/04 (2013.01); C07F 9/65515 (2013.01);
Abstract
Prodrugs and derivatives of 5-hydoxymethyl-2-furfural (5-HMF) with protected or modified aldehyde and/or alcohol moieties are provided. The prodrugs or derivatives exhibit increased bioavailability, e.g. due to having extended half-lives in circulation. The drugs are therefore administered i) at lower doses and/or ii) less frequently than 5-HMF, while still maintaining the beneficial therapeutic effects of 5-HMF.