The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 29, 2020
Filed:
Dec. 20, 2019
Applicant:
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Inventors:
Martin John Schnermann, Rockville, MD (US);
Roger Rauhauser Nani, Frederick, MD (US);
Alexander Patrick Gorka, Frederick, MD (US);
Hisataka Kobayashi, Laurel, MD (US);
Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 49/00 (2006.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01); A61K 41/00 (2020.01); A61K 47/54 (2017.01);
U.S. Cl.
CPC ...
A61K 41/0042 (2013.01); A61K 47/545 (2017.08); A61K 47/6803 (2017.08); A61K 47/6829 (2017.08); A61K 47/6845 (2017.08); A61K 49/0032 (2013.01); A61K 49/0058 (2013.01); A61P 35/00 (2018.01);
Abstract
Embodiments of near-infrared light-cleavable heptamethine cyanine-based conjugates, particularly targeting agent-drug conjugates, according to Formula I and conjugate precursors are disclosed. The disclosed targeting agent-drug conjugates are useful for targeted delivery and release of a drug. Methods of making and using the conjugates and precursors also are disclosed.