The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 29, 2020
Filed:
Dec. 18, 2017
Applicant:
New York University, New York, NY (US);
Inventors:
Karsten Henco, Düsseldorf, DE;
Roger Nitsch, Zumikon, CH;
Jan Grimm, Dübendorf, CH;
Anja Zeller, Zürich, CH;
Marcel Maier, Zürich, CH;
Assignee:
New York University, New York, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 39/39 (2006.01); A61K 31/7088 (2006.01); C12N 15/117 (2010.01); A61P 25/28 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
A61K 39/0007 (2013.01); A61K 31/7088 (2013.01); A61K 39/39 (2013.01); G01N 33/6896 (2013.01); A61K 2039/53 (2013.01); A61K 2039/545 (2013.01); A61K 2039/55511 (2013.01); A61K 2039/55561 (2013.01); A61K 2039/57 (2013.01); A61K 2039/575 (2013.01); A61P 25/28 (2018.01); C12N 15/117 (2013.01); G01N 2333/4709 (2013.01); Y02A 50/30 (2018.01);
Abstract
A treatment of Alzheimer's disease and other disorders involving protein misfolding or aggregation is provided by enhancing or sustaining an antibody response against predominantly directed against pathological protein aggregates or neo-epitopes present on pathogenic forms of said protein or protein complex. Furthermore, therapeutic methods are described, wherein ex vivo stimulated antigen-selected peripheral blood lymphocytes are regrafted into the cognate donor.