The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 29, 2020
Filed:
Nov. 14, 2017
Erasmus University Medical Center Rotterdam, Rotterdam, NL;
Jacobus Johannes Maria van Dongen, Rotterdam, NL;
José Alberto Orfao de Matos Correia e Vale, Salamanca, ES;
Juan Alejandro Flores Montero, Salamanca, ES;
Julia Maria Almeida Parra, Salamanca, ES;
Vincent Henricus Johannes Van der Velden, Rotterdam, NL;
Sebastian Böttcher, Kiel, DE;
Anthonie Willem Langerak, Rotterdam, NL;
Ester Mejst{hacek over (r)}íková, Prague, CZ;
Tomasz Szczepański, Zabrze, PL;
Matthias Ritgen, Kiel, DE;
Paulo Jorge Monteiro Da Silva Lucio, Lisbon Codex, PT;
Erasmus University Medical Center Rotterdam, Rotterdam, NL;
Abstract
The invention relates to the field of minimal residual disease (MRD) diagnostics, which is progressively more applied for the evaluation of treatment effectiveness in patients with a hematological malignancy, such as B-cell precursor acute lymphoblastic leukemia (BCP-ALL), B-cell chronic lymphocytic leukemia (B-CLL), and multiple myeloma (MM). Provided are unique reagent compositions with carefully selected and thoroughly tested combinations of antibodies, for ≥8-color flow cytometric stainings as well as for 10-color and 12-color flow cyometric stainings, which can reach sensitivities of at least 10, even down to 10. Also provided are diagnostic kits and methods for detecting MRD.