The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 29, 2020

Filed:

Sep. 15, 2016
Applicants:

Massachusetts Institute of Technology, Cambridge, MA (US);

Connecticut Children's Medical Center, Hartford, CT (US);

Inventors:

Rishikesh Pandey, Arlington, MA (US);

Nicolas Spegazzini, Arlington, MA (US);

Luis H. Galindo, Fitchburg, MA (US);

Ramachandra Dasari, Shererville, IN (US);

Tulio Alberto Valdez, Simsbury, CT (US);

Assignees:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61B 5/00 (2006.01); A61B 5/12 (2006.01); A61B 5/1459 (2006.01); A61B 1/07 (2006.01); A61B 1/227 (2006.01); A61B 1/00 (2006.01); A61B 5/145 (2006.01); A61B 1/04 (2006.01); A61B 1/32 (2006.01); A61B 1/06 (2006.01); G01N 21/65 (2006.01); G01J 3/44 (2006.01); G01J 3/02 (2006.01); G01N 21/64 (2006.01);
U.S. Cl.
CPC ...
A61B 5/12 (2013.01); A61B 1/00009 (2013.01); A61B 1/00045 (2013.01); A61B 1/043 (2013.01); A61B 1/0638 (2013.01); A61B 1/0684 (2013.01); A61B 1/07 (2013.01); A61B 1/227 (2013.01); A61B 1/32 (2013.01); A61B 5/0075 (2013.01); A61B 5/0084 (2013.01); A61B 5/1459 (2013.01); A61B 5/14532 (2013.01); A61B 5/14546 (2013.01); A61B 5/6817 (2013.01); A61B 5/7282 (2013.01); G01J 3/0218 (2013.01); G01J 3/44 (2013.01); G01J 3/4406 (2013.01); G01N 21/65 (2013.01); A61B 5/0071 (2013.01); G01N 21/6486 (2013.01);
Abstract

Systems and methods are presented for the diagnosis of middle ear pathological conditions based on spectral signatures. Preferred embodiments provide for detection of one or more analytes from the tympanic membrane. Devices use spectral measurements including spectral imaging to non-invasively identify middle ear pathological conditions including cholesteatoma and acute otitis media by providing real-time information of differentially expressed molecules. Devices and methods can also be used to non-invasively detect and quantify blood analytes from the tympanic membrane.


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