The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 22, 2020

Filed:

May. 12, 2017
Applicant:

Flash Therapeutics, Toulouse, FR;

Inventors:

Pascale Bouille, Vincennes, FR;

Régis Gayon, Ramonville Saint-Agne, FR;

Lucille Lamouroux, Pinsaguel, FR;

Alexandra Iche, Corronsac, FR;

Assignee:

FLASH THERAPEUTICS, Toulouse, FR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/21 (2006.01); C12N 7/00 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61K 39/12 (2006.01); C12N 15/86 (2006.01); C07K 14/005 (2006.01); C12N 15/90 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); C07K 14/005 (2013.01); C12N 7/00 (2013.01); C12N 15/907 (2013.01); C07K 2319/735 (2013.01); C07K 2319/85 (2013.01); C12N 2310/20 (2017.05); C12N 2740/16023 (2013.01); C12N 2740/16043 (2013.01); C12N 2740/16052 (2013.01); C12N 2795/18122 (2013.01); C12N 2800/24 (2013.01); C12N 2800/30 (2013.01); C12N 2800/50 (2013.01);
Abstract

The present invention relates to a retroviral particle comprising a protein derived from the Gag polyprotein, an envelope protein, optionally an integrase and at least two encapsidated non-viral RNAs, the encapsidated non-viral RNAs each comprising an RNA sequence of interest bound to an encapsidation sequence, each encapsidation sequence being recognized by a binding domain introduced into the protein derived from the Gag polyprotein and/or into the integrase, and at least one of said sequences of interest of the encapsidated non-viral RNAs comprises a part coding a nuclease.


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