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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10870689 B1

PDFFull Text
Date of Patent:
Dec. 22, 2020

Filed:

Aug. 15, 2017

Apom-fc fusion proteins, complexes thereof with sphingosine 1-phosphate (s1p), and methods for treating vascular and non-vascular diseases

Applicant:

Children's Medical Center Corporation, Boston, MA (US);

Inventors:

Timothy T. Hla, Wellesley, MA (US);

Steven L. Swendeman, Cambridge, MA (US);

Annarita DiLorenzo, Ithaca, NY (US);

Teresa Sanchez, Ithaca, NY (US);

Assignee:

The Children's Medical Center Corporation, Boston, MA (US);

Attorney:

Wolf, Greenfield & Sacks, P.C.

Primary Examiner:

Zachary C Howard

Int. Cl.
CPC ...
C07K 14/775 (2006.01); C07K 19/00 (2006.01); A61K 38/17 (2006.01); A61K 8/55 (2006.01); A61P 9/10 (2006.01); A61P 9/02 (2006.01); C07K 14/00 (2006.01); A61K 9/00 (2006.01); A61K 47/54 (2017.01); A61P 9/12 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/775 (2013.01); A61K 8/553 (2013.01); A61K 9/0019 (2013.01); A61K 38/1709 (2013.01); A61K 47/544 (2017.08); A61P 9/02 (2018.01); A61P 9/10 (2018.01); A61P 9/12 (2018.01); C07K 14/00 (2013.01); C07K 19/00 (2013.01); A61K 38/00 (2013.01); C07K 2319/30 (2013.01);
Abstract

The present disclosure is directed to an engineered phospholipid or lysophospholipid (e.g., sphingosine 1-phosphate (S1P)) chaperone derived from an Apolipoprotein M (ApoM)-Fc fusion protein having an extended half life in vivo. The disclosed ApoM-Fc fusion protein provides a safe, efficient and effective means of delivering S1P to endothelial cells and to all tissues of the body.

Find Patent Forward Citations

Hla, Timothy. (2020). Apom-fc fusion proteins, complexes thereof with sphingosine 1-phosphate (s1p), and methods for treating vascular and non-vascular diseases (U.S. Patent No. 10870689). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10870689

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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