The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 22, 2020
Filed:
Aug. 20, 2018
Applicant:
The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);
Inventors:
William Messer, Portland, OR (US);
Ralph Baric, Haw River, NC (US);
Aravinda de Silva, Chapel Hill, NC (US);
Boyd Yount, Hillsborough, NC (US);
Assignee:
The University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/12 (2006.01); C07K 14/005 (2006.01); C07K 16/10 (2006.01); C12N 7/00 (2006.01); C07K 14/18 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/005 (2013.01); C07K 14/1825 (2013.01); C07K 16/1081 (2013.01); C12N 7/00 (2013.01); A61K 39/00 (2013.01); A61K 39/12 (2013.01); C07K 2317/76 (2013.01); C07K 2319/00 (2013.01); C12N 2770/24122 (2013.01); C12N 2770/24134 (2013.01); Y02A 50/30 (2018.01);
Abstract
The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.