The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 22, 2020

Filed:

Sep. 17, 2019
Applicant:

Dalian Medical University, Liaoning, CN;

Inventors:

Jie Zhao, Liaoning, CN;

Shao Li, Liaoning, CN;

Wanqin Zhang, Liaoning, CN;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C07K 7/00 (2006.01); A61P 25/28 (2006.01); A61K 38/10 (2006.01); A61K 35/646 (2015.01); A61P 25/08 (2006.01); A61P 25/14 (2006.01); A61P 25/00 (2006.01); C07K 14/435 (2006.01); C07K 7/08 (2006.01); A61P 25/16 (2006.01); A61K 47/64 (2017.01); A61K 47/68 (2017.01); A61P 29/00 (2006.01); A61P 25/02 (2006.01); A61P 25/04 (2006.01); A61K 38/02 (2006.01);
U.S. Cl.
CPC ...
C07K 7/08 (2013.01); A61P 25/08 (2018.01); A61P 25/16 (2018.01); A61P 25/28 (2018.01); C07K 14/43522 (2013.01); A61K 38/00 (2013.01); A61K 38/02 (2013.01); A61K 47/6415 (2017.08); A61K 47/6817 (2017.08); A61K 2300/00 (2013.01); A61P 25/02 (2018.01); A61P 25/04 (2018.01); A61P 29/00 (2018.01); C07K 14/43504 (2013.01); C07K 14/43518 (2013.01); C12N 2310/3513 (2013.01);
Abstract

A scorpion venom heat-resistant synthetic peptide (SVHRSP) contains an amino acid sequence of SEQ ID NO 1. One or more amino acids the amino acid sequence can be substituted or deleted. A pharmaceutical composition that contains the SVHRSP has numerous applications. The pharmaceutical composition can be used to protect neuronal cell against amyloid beta-induced toxic effects, or to inhibit the sodium channel current of a hippocampal neuronal cell, or to protect a neuronal cell against NMDA-induced injury. It may also promote the formation of a pluripotent neural stem cell from a type II astrocyte, or treats a subject, such as a human, having epilepsy, Alzheimer's disease, or Parkinson's disease.


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