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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10870635 B1

PDFFull Text
Date of Patent:
Dec. 22, 2020

Filed:

Apr. 20, 2016

Compounds and their use as bace1 inhibitors

Applicant:

Allgenesis Biotherapeutics, Inc., Taipei, TW;

Inventors:

Madhu Cherukury, Taipei, TW;

Hsiao-Wen Lin, Taipei, TW;

Shu Chieh Yu, Taipei, TW;

Riping Phang, Taipei, TW;

Yesudoss Christu Rajan, Taipei, TW;

Diane Dan-Shya Tang-Liu, Taipei, TW;

Andrew D. White, Taipei, TW;

Thomas Malone, Taipei, TW;

Richard Beresis, Taipei, TW;

Assignee:

ALLGENESIS BIOTHERAPEUTICS, INC., Taipei, TW;

Attorney:

Ice Miller LLP

Primary Examiner:

Irina Neagu

Int. Cl.
CPC ...
C07D 239/22 (2006.01); C07D 405/04 (2006.01); C07D 409/04 (2006.01); C07D 413/04 (2006.01); C07D 417/04 (2006.01); C07D 471/04 (2006.01); C07D 491/048 (2006.01); C07D 513/10 (2006.01); A61P 25/28 (2006.01); C07D 403/04 (2006.01); C07D 405/14 (2006.01); C07D 401/04 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 403/06 (2006.01); C07D 403/10 (2006.01); C07D 409/14 (2006.01); C07D 413/08 (2006.01); C07D 417/08 (2006.01); C07D 417/14 (2006.01); C07D 471/14 (2006.01); C07D 495/04 (2006.01); C07D 498/04 (2006.01);
U.S. Cl.
CPC ...
C07D 403/04 (2013.01); A61P 25/28 (2018.01); C07D 239/22 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 403/06 (2013.01); C07D 403/10 (2013.01); C07D 405/04 (2013.01); C07D 405/14 (2013.01); C07D 409/04 (2013.01); C07D 409/14 (2013.01); C07D 413/04 (2013.01); C07D 413/08 (2013.01); C07D 417/04 (2013.01); C07D 417/08 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 471/14 (2013.01); C07D 491/048 (2013.01); C07D 495/04 (2013.01); C07D 498/04 (2013.01); C07D 513/10 (2013.01);
Abstract

The present invention relates to compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein X, Y, Z, Q, W, m, u, ring (A), R, R, R, Rand R, are as defined in the specification and claims. The present invention provides a pharmaceutical composition containing the compounds of Formula (I) and a therapeutic method of treating and/or preventing Downs syndrome, 3-amyloid angiopathy, disorders associated with cognitive impairment, Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegenerative diseases, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, Alzheimer's disease and/or Down syndrome, age-related macular degeneration (AMD), glaucoma, olfactory function impairment, traumatic brain injury, progressive muscle diseases, Type II diabetes mellitus and cardiovascular diseases (stroke).

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