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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10869931 B1

PDFFull Text
Date of Patent:
Dec. 22, 2020

Filed:

Mar. 07, 2017

Polyethylene glycol-modified angiogenesis inhibitor hm-1 and application thereof

Applicant:

Nanjing Anji Biological Technology Co.,ltd, Nanjing, CN;

Inventor:

Hanmei Xu, Nanjing, CN;

Assignee:

NANJING ANJI BIOLOGICAL TECHNOLOGY CO., LTD, Nanjing, CN;

Attorneys:

Zhihua Han

Wen IP LLC

Primary Examiner:

Julie Ha

Int. Cl.
CPC ...
A61K 38/10 (2006.01); A61K 47/60 (2017.01); C07K 7/08 (2006.01); A61P 19/02 (2006.01); A61P 27/02 (2006.01); A61P 35/00 (2006.01); A61P 29/00 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/60 (2017.08); A61K 9/0019 (2013.01); A61K 38/10 (2013.01); A61P 19/02 (2018.01); A61P 27/02 (2018.01); A61P 29/00 (2018.01); A61P 35/00 (2018.01); C07K 7/08 (2013.01);
Abstract

A polyethylene glycol-modified angiogenesis inhibitor HM-1 and its application are disclosed. The polypeptide sequence is mPEG-Arg-Gly-Ala-Asp-Arg-Ala-Gly-Gly-Gly-Gly-Arg-Gly-Asp (SEQ ID NO: 1), and mPEG . . . is chosen from mPEG-SC, mPEG2-NHS, mPEG-ALD or mPEG-bALD, with a molecular weight range of 500˜40000. The polypeptide has been modified by polyethylene glycol, has the capacity to inhibit vascular endothelial cell migration and integrin affinity and binding, and can be used for the prevention and treatment of tumors, various types of inflammation, and neovascular eye diseases. The polyethylene glycol-modified angiogenesis inhibitor disclosed by the present invention is prepared by a synthetic method.

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Xu, Hanmei. (2020). Polyethylene glycol-modified angiogenesis inhibitor hm-1 and application thereof (U.S. Patent No. 10869931). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10869931

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