The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 22, 2020

Filed:

Jul. 03, 2017
Applicant:

Universiteit Gent, Ghent, BE;

Inventors:

Richard Hoogenboom, Terneuzen, NL;

Bart Verbraeken, Lummen, BE;

Assignee:

UNIVERSITEIT GENT, Ghent, BE;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/59 (2017.01); C08G 73/02 (2006.01); A61K 47/69 (2017.01); C12N 15/87 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/59 (2017.08); A61K 47/6907 (2017.08); A61K 48/0008 (2013.01); C08G 73/0233 (2013.01); C12N 15/87 (2013.01);
Abstract

The invention relates to invention relates to a statistical copolymer represented by the following formula (I): Ini-[Ox]-[Oz]-Nuc (I) wherein: Ini represents a residue of an initiator of cationic polymerization, Nuc represents a residue of a nucleophilic agent, Ox represents N(R)CHRCHR; each Rindependently represents H or C(O)R; and Rindependently represents optionally substituted Calkyl, optionally substituted cycloalkyl, optionally substituted aralkyl or optionally substituted aryl; Oz represents N(R)CHRCHRCHR; each Rindependently represents C(O)Ror H; and Rindependently represents optionally substituted Calkyl, optionally substituted cycloalkyl, optionally substituted aralkyl or optionally substituted aryl; each Rindependently represents H, linear or branched Calkyl; m≥5; n≥5; m+n≥20; 3:97≤m:n≤97:3. The statistical copolymers of the present invention exhibit useful properties that can be exploited in the medical field, especially in polymer micelles for drug delivery and polyplexes for DNA delivery.


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