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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10869863 B1

PDFFull Text
Date of Patent:
Dec. 22, 2020

Filed:

May. 15, 2017

Multi-arm polymeric targeting anti-cancer conjugate

Applicant:

Brightgene Bio-medical Technology Co., Ltd., Jiangsu, CN;

Inventors:

Jiandong Yuan, Jiangsu, CN;

Yangqing Huang, Jiangsu, CN;

Yunsong Song, Jiangsu, CN;

Fang Yuan, Jiangsu, CN;

Assignee:

BrightGene Bio-Medical Technology Co., Ltd., Suzhou, CN;

Attorney:

Fish & Richardson P.C.

Primary Examiner:

Charanjit Aulakh

Int. Cl.
CPC ...
C07D 491/22 (2006.01); A61K 31/4745 (2006.01); A61K 47/58 (2017.01); A61K 47/54 (2017.01); A61K 47/64 (2017.01); A61K 47/60 (2017.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4745 (2013.01); A61K 47/545 (2017.08); A61K 47/58 (2017.08); A61K 47/60 (2017.08); A61K 47/64 (2017.08); A61P 35/00 (2018.01);
Abstract

Disclosed is a multi-arm targeting drug conjugate modified by a water-soluble polymer; the drug conjugate has the structural formula of (III). In formula (III), R is an organic core, POLY is a polymer, L is a multivalent linker, T is a targeting molecule, D is a camptothecin-based drug, and q is any integer between 3 and 8. The drug conjugate may improve the poor water solubility, high toxicity and low bioavailability of camptothecin-based drugs.

Find Patent Forward Citations

Yuan, Jiandong. (2020). Multi-arm polymeric targeting anti-cancer conjugate (U.S. Patent No. 10869863). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10869863

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