The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 15, 2020

Filed:

May. 25, 2018
Applicant:

Abbott Laboratories, Abbott Park, IL (US);

Inventors:

Beth McQuiston, Abbott Park, IL (US);

Justin Rogers, Abbott Park, IL (US);

Jaime Marino, Abbott Park, IL (US);

Raj Chandran, Abbott Park, IL (US);

Tianming Zhang, Abbott Park, IL (US);

Saul Datwyler, Abbott Park, IL (US);

Assignee:

Abbott Laboratories, Abbott Park, IL (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C12Q 1/68 (2018.01); G01N 33/567 (2006.01); G01N 33/68 (2006.01); A61B 5/055 (2006.01); A61B 6/03 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6893 (2013.01); A61B 5/055 (2013.01); A61B 6/03 (2013.01); G01N 2333/918 (2013.01); G01N 2800/60 (2013.01);
Abstract

Disclosed herein are methods that aid in the determination of whether to perform imaging, such as magnetic resonance imaging (MRI) or computerized tomography (CT) scan, on a human subject that has sustained or may have sustained an injury to the head using an early biomarker, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof. These methods involve detecting levels and changes in levels of UCH-L1 in samples taken from a human subject at time points within 24 hours after the subject has sustained or may have sustained an injury to the head.


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