The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 15, 2020
Filed:
Sep. 07, 2012
Anthony D. Keefe, Cambridge, MA (US);
Richard W. Wagner, Cambridge, MA (US);
Alexander Litovchick, Sudbury, MA (US);
Matthew Clark, Lexington, MA (US);
John W. Cuozzo, Natick, MA (US);
Ying Zhang, Lexington, MA (US);
Paolo A. Centrella, Acton, MA (US);
Christopher D. Hupp, Shrewsbury, MA (US);
Anthony D. Keefe, Cambridge, MA (US);
Richard W. Wagner, Cambridge, MA (US);
Alexander Litovchick, Sudbury, MA (US);
Matthew Clark, Lexington, MA (US);
John W. Cuozzo, Natick, MA (US);
Ying Zhang, Lexington, MA (US);
Paolo A. Centrella, Acton, MA (US);
Christopher D. Hupp, Shrewsbury, MA (US);
X-Chem, Inc., Waltham, MA (US);
Abstract
The present invention relates to oligonucleotide-encoded libraries and methods of tagging such libraries. In particular, the methods and oligonucleotides can include one or more 2'-substituted nucleotides, such as 2′-O-methyl or 2′-fluoro nucleotides, and other conditions or reagents to enhance enzyme ligation or one or more chemical functionalities to support chemical ligation.