The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 15, 2020
Filed:
May. 11, 2018
Applicant:
Board of Regents, the University of Texas System, Austin, TX (US);
Inventors:
Assignee:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/88 (2006.01); C07K 14/76 (2006.01); C07K 14/00 (2006.01); A61K 47/61 (2017.01); A61K 47/60 (2017.01); A61P 35/00 (2006.01); A61K 38/38 (2006.01); A61K 38/51 (2006.01); A61K 38/16 (2006.01); A61K 9/00 (2006.01); A61K 45/06 (2006.01); A61K 31/7076 (2006.01); A61B 17/225 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/88 (2013.01); A61B 17/225 (2013.01); A61K 9/0019 (2013.01); A61K 31/7076 (2013.01); A61K 38/16 (2013.01); A61K 38/38 (2013.01); A61K 38/51 (2013.01); A61K 45/06 (2013.01); A61K 47/60 (2017.08); A61K 47/61 (2017.08); A61P 35/00 (2018.01); C07K 14/001 (2013.01); C07K 14/76 (2013.01); C12Y 404/01001 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/30 (2013.01);
Abstract
Methods and compositions related to the engineering of a protein with L-cyst(e)ine degrading enzyme activity are described. For example, disclosed are modified cystathionine-γ-lyases comprising one or more amino acid substitutions and capable of degrading L-cyst(e)ine. Furthermore, compositions and methods are provided for the treatment of cancer and cystinuria using the disclosed modified enzymes or nucleic acids encoding said enzymes.