The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 15, 2020
Filed:
Sep. 24, 2014
Applicant:
National Taiwan University, Taipei, TW;
Inventors:
Assignee:
NATIONAL TAIWAN UNIVERSITY, Taipei, TW;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/50 (2006.01); C12N 5/095 (2010.01); C12N 5/09 (2010.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0695 (2013.01); C12N 5/0693 (2013.01); G01N 33/5011 (2013.01); G01N 33/5017 (2013.01); G01N 33/574 (2013.01); G01N 33/57492 (2013.01); G01N 33/57496 (2013.01); C12N 2501/605 (2013.01); C12N 2502/30 (2013.01); G01N 2333/475 (2013.01); G01N 2333/4706 (2013.01); G01N 2333/4753 (2013.01); G01N 2333/52 (2013.01); G01N 2333/71 (2013.01); G01N 2333/715 (2013.01); G01N 2333/7158 (2013.01); G01N 2800/52 (2013.01);
Abstract
An in vitro co-culture system comprising cancer-associated fibroblasts (CAFs) and cancer cells for producing and maintaining cancer stem cells and uses thereof for identifying agents capable of reducing cancer cell stemness. Also disclosed herein are a paracrine network through which CAFs facilitate production and/or maintenance of cancer stem cells and the use of components of such a paracrine network for prognosis purposes and for identifying cancer patients who are likely to respond to certain treatment.