The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 15, 2020
Filed:
May. 06, 2019
Applicant:
Innovative Cellular Therapeutics Co., Ltd., Shanghai, CN;
Inventor:
Zhao Wu, Shanghai, CN;
Assignee:
Innovative Cellular Therapeutics Co., Ltd., Shanghai, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/705 (2006.01); A61K 39/00 (2006.01); C12N 5/0783 (2010.01); C07K 16/28 (2006.01); C07K 14/725 (2006.01); A61K 35/17 (2015.01); C07K 16/30 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0636 (2013.01); A61K 35/17 (2013.01); A61K 39/0011 (2013.01); A61K 39/001112 (2018.08); C07K 14/7051 (2013.01); C07K 14/70503 (2013.01); C07K 14/70521 (2013.01); C07K 16/2803 (2013.01); C07K 16/30 (2013.01); C12N 5/0638 (2013.01); A61K 2039/5156 (2013.01); A61K 2039/5158 (2013.01); C07K 2319/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C12N 2510/02 (2013.01);
Abstract
The present disclosure relates to compositions and methods for reducing immune tolerance associated with CAR T cell therapy. Embodiments of the present disclosure include isolated nucleic acid sequence comprising a nucleic acid sequence that encodes modified programmed cell death protein 1 (PD-1) and a nucleic acid sequence that encodes chimeric antigen receptor (CAR).