Bispecific antigen-binding molecules that bind atarget antigen and a complement component and uses thereof

Abstract

According to certain embodiments, the present disclosure provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds aspecies target antigen and a second antigen binding domain that binds a complement component. In certain embodiments, the bispecific antigen-binding molecules of the present disclosure are capable of binding to thespecies target antigen with an ECof about 10 nM or less, and/or are capable of promoting complement deposition on thespecies with an ECof about 10 nM. The antibodies of the disclosure are useful for treating diseases in which inhibition or reduction of the growth of aspecies is desired and/or therapeutically beneficial, for example, for treating staphylococcal infections including a skin infection, cellulitis, pneumonia, meningitis, urinary tract infection, toxic shock syndrome, endocarditis, osteomyelitis, bacteremia, or sepsis, or for preventing or treating ainfection that occurs as a result of a surgical procedure.