The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 15, 2020

Filed:

Aug. 02, 2016
Applicant:

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

Hai-Yun Xiao, Belle Mead, NJ (US);

T. G. Murali Dhar, Newtown, PA (US);

Ning Li, Basking Ridge, NJ (US);

Jingwu Duan, Yardley, PA (US);

Bin Jiang, Bryn Mawr, PA (US);

Zhonghui Lu, King of Prussia, PA (US);

Khehyong Ngu, Pennington, NJ (US);

William J. Pitts, Newtown, PA (US);

Joseph A. Tino, Lawrenceville, NJ (US);

Assignee:

Bristol-Myers Squibb Company, Princeton, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/00 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 215/42 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 471/04 (2006.01); C07D 215/44 (2006.01); C07D 401/12 (2006.01);
U.S. Cl.
CPC ...
C07D 401/04 (2013.01); C07D 215/42 (2013.01); C07D 215/44 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01);
Abstract

Disclosed are compounds of Formula (I) or a salt thereof, wherein: A is CRor N; B is CRor N; D is CRor N; Lis —(CRR)—; Lis —(CRR)—; and X, Z, R, R, R, R, R, and Rare define herein. Also disclosed are methods of using such compounds as modulators of TNFα, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.


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