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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10864211 B1

PDFFull Text
Date of Patent:
Dec. 15, 2020

Filed:

Dec. 11, 2017

Hydroxy isoxazole compounds useful as gpr120 agonists

Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

John S. Debenham, Scotch Plains, NJ (US);

Jason M. Cox, Whitehouse Station, NJ (US);

Ping Lan, Plainsboro, NJ (US);

Zhongxiang Sun, Princeton, NJ (US);

Zhe Feng, Hillsborough, NJ (US);

Chunrui Sun, Westfield, NJ (US);

W. Michael Seganish, Castro Valley, CA (US);

Zhong Lai, East Brunswick, NJ (US);

Cheng Zhu, Edison, NJ (US);

Thomas Bara, Scotch Plains, NJ (US);

Murali Rajagopalan, Edison, NJ (US);

Qun Dang, Westfield, NJ (US);

Hyunjin M. Kim, Livingston, NJ (US);

Bin Hu, Shanghai, CN;

Jinglai Hao, Shanghai, CN;

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:

Baerbel R. Brown

Catherine D. Fitch

Primary Examiner:

Kamal A Saeed

Int. Cl.
CPC ...
A61K 31/497 (2006.01); A61K 31/4439 (2006.01); A61K 31/42 (2006.01); A61K 31/444 (2006.01); C07D 417/14 (2006.01); C07D 413/04 (2006.01); C07D 413/14 (2006.01); C07D 231/20 (2006.01); A61P 43/00 (2006.01); A61P 3/10 (2006.01); A61K 9/48 (2006.01); A61K 9/00 (2006.01); C07D 261/12 (2006.01);
U.S. Cl.
CPC ...
A61K 31/497 (2013.01); A61K 9/0053 (2013.01); A61K 9/4858 (2013.01); A61K 31/42 (2013.01); A61K 31/444 (2013.01); A61K 31/4439 (2013.01); A61P 3/10 (2018.01); A61P 43/00 (2018.01); C07D 231/20 (2013.01); C07D 261/12 (2013.01); C07D 413/04 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01);
Abstract

The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, NASH, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.

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