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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10864190 B1

PDFFull Text
Expired
Date of Patent:
Dec. 15, 2020

Filed:

Apr. 22, 2016

Combination of an antiandrogen with a vitamin k antagonist or with a gamma-glutamyl carboxylase inhibitor for the therapy of androgen receptor positive cancer

Applicant:

Cemm—forschungszentrum Für Molekulare Medizin Gmbh, Vienna, AT;

Inventors:

Stefan Kubicek, Vienna, AT;

Marco Licciardello, London, GB;

Assignee:

CEMM—FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GMBH, Vienna, AT;

Attorney:

Parker Highlander PLLC

Primary Examiner:

Sarah Pihonak

Assistant Examiner:

Jason Deck

Int. Cl.
CPC ...
A61K 31/37 (2006.01); A61K 31/167 (2006.01); A61P 35/00 (2006.01); A61K 31/4166 (2006.01);
U.S. Cl.
CPC ...
A61K 31/37 (2013.01); A61K 31/167 (2013.01); A61K 31/4166 (2013.01); A61P 35/00 (2018.01);
Abstract

The present invention relates to the combination of an antiandrogen with a vitamin K antagonist or with a γ-glutamyl carboxylase inhibitor for use in the treatment or prevention of an androgen receptor positive cancer, such as prostate cancer, or a hyperactive androgen receptor signaling disease/disorder. The invention also relates to a vitamin K antagonist or a γ-glutamyl carboxylase inhibitor for use in resensitizing an antiandrogen-resistant prostate cancer to the treatment with an antiandrogen. The invention further provides a pharmaceutical composition comprising an antiandrogen, a vitamin K antagonist or a γ-glutamyl carboxylase inhibitor, and a pharmaceutically acceptable excipient.

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Kubicek, Stefan. (2020). Combination of an antiandrogen with a vitamin k antagonist or with a gamma-glutamyl carboxylase inhibitor for the therapy of androgen receptor positive cancer (U.S. Patent No. 10864190). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10864190

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