The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 15, 2020
Filed:
Sep. 08, 2016
Applicant:
Stichting Het Nederlands Kanker Instituut-antoni Van Leeuwenhoek Ziekenhuis, Amsterdam, NL;
Inventors:
Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/167 (2006.01); A61K 31/454 (2006.01); A61K 31/4406 (2006.01); A61K 31/4184 (2006.01); A61K 31/506 (2006.01); A61K 31/4045 (2006.01); A61K 31/18 (2006.01); A61K 31/15 (2006.01); A61P 35/00 (2006.01); A61K 45/06 (2006.01); A61K 31/635 (2006.01); A61K 31/437 (2006.01); A61K 31/713 (2006.01); A61K 31/519 (2006.01); A61K 38/15 (2006.01); A61K 31/517 (2006.01);
U.S. Cl.
CPC ...
A61K 31/167 (2013.01); A61K 31/18 (2013.01); A61K 31/4045 (2013.01); A61K 31/4184 (2013.01); A61K 31/437 (2013.01); A61K 31/4406 (2013.01); A61K 31/454 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); A61K 31/635 (2013.01); A61K 31/713 (2013.01); A61K 38/15 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); A61K 31/517 (2013.01); A61K 2300/00 (2013.01);
Abstract
The current invention relates to treatment of drug resistant melanoma with histone deacetylase inhibitors (HDACi). In particular the invention relates to BRAF and NRAS mutated melanoma and that have acquired resistance to MAPK pathway inhibitors, for example due to previous treatment with such MAPK pathway inhibitors. The invention discloses HDACi and/or MAPK pathway inhibitors for use in such treatment and treatment regimens using such inhibitors.