The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 08, 2020

Filed:

Dec. 18, 2019
Applicant:

Nour Heart, Inc., Vienna, VA (US);

Inventor:

Salwa Ahmed Elgebaly, Vienna, VA (US);

Assignee:

Other;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07H 21/04 (2006.01); G01N 33/566 (2006.01); C07K 16/24 (2006.01); G01N 33/563 (2006.01); G16H 50/50 (2018.01); G16H 10/40 (2018.01); G16H 10/60 (2018.01); G16H 50/30 (2018.01); G16H 50/70 (2018.01); G16H 50/20 (2018.01); G16H 20/10 (2018.01); G16B 20/20 (2019.01); C12Q 1/686 (2018.01); C12Q 1/6883 (2018.01);
U.S. Cl.
CPC ...
G01N 33/566 (2013.01); C07K 16/24 (2013.01); C12Q 1/686 (2013.01); C12Q 1/6883 (2013.01); G01N 33/563 (2013.01); G16B 20/20 (2019.02); G16H 10/40 (2018.01); G16H 10/60 (2018.01); G16H 20/10 (2018.01); G16H 50/20 (2018.01); G16H 50/30 (2018.01); G16H 50/50 (2018.01); G16H 50/70 (2018.01); C12Q 2600/112 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/178 (2013.01); G01N 2800/325 (2013.01); G01N 2800/50 (2013.01); G01N 2800/56 (2013.01);
Abstract

The present invention provides a molecular network, devices, and assays for early diagnosis of angina patients experiencing acute chest pain with negative Troponin, and it reflects on disease progression and severity. The invention also allows for the diagnosis of angina in suspected patients with history of chest pain; differentiates between angina patients and acute myocardial infarction; as well as diagnose coronary artery disease patients from other non-cardiac and healthy individuals. The present invention indicates that the downregulation of Nourin lncCTB9H12.4 in coronary artery disease patients compared to non-cardiac and healthy controls, is significantly associated with upregulation of miR_106b and miR_137 resulting in overexpression of mRNA ANAPC11 and mRNA FTLH-17; respectively. Therefore, the invention provides a novel non-invasive good positive test to diagnose angina patients which also, has a good negative test to exclude chest pain non-angina patients and healthy individuals.


Find Patent Forward Citations

Elgebaly, Salwa. (2020). Nourin molecular biomarkers diagnose angina patients with negative troponin (U.S. Patent No. 10859573). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10859573

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