The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 08, 2020
Filed:
Aug. 19, 2019
Applicant:
Codexis Inc., Redwood City, CA (US);
Inventors:
Steven J. Collier, Concord, MA (US);
Ee Ling Teo, Mauchline East Ayrshire, GB;
Joly Sukumaran, Singapore, SG;
Robert J. Wilson, San Francisco, CA (US);
Junye Xu, Singapore, SG;
Assignee:
Codexis, Inc., Redwood City, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P 17/06 (2006.01); C12N 9/10 (2006.01); C12P 7/62 (2006.01); C07K 14/00 (2006.01); C12N 15/52 (2006.01);
U.S. Cl.
CPC ...
C12P 17/06 (2013.01); C07K 14/00 (2013.01); C12N 9/1025 (2013.01); C12N 9/1029 (2013.01); C12N 15/52 (2013.01); C12P 7/62 (2013.01); C12Y 203/01 (2013.01); Y02P 20/52 (2015.11);
Abstract
Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.