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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10858654 B1

PDFFull Text
Date of Patent:
Dec. 08, 2020

Filed:

Nov. 08, 2018

Polypeptide inhibitors of smad3 polypeptide activities

Applicant:

Mayo Foundation for Medical Education and Research, Rochester, MN (US);

Inventors:

Edward B. Leof, Rochester, MN (US);

Mark C. Wilkes, Plainview, MN (US);

Claire E. Repellin, Alameda, CA (US);

Jeong-Han Kang, Rochester, MN (US);

Xueqian Yin, Rochester, MN (US);

Mahefatiana Andrianifahanana, Rochester, MN (US);

Assignee:

Mayo Foundation for Medical Education and Research, Rochester, MN (US);

Attorney:

Fish & Richardson P.C.

Primary Examiner:

Thea D'Ambrosio

Int. Cl.
CPC ...
A61K 38/16 (2006.01); A61K 38/00 (2006.01); C07K 5/00 (2006.01); C07K 7/00 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01); C12N 15/113 (2010.01); C12N 15/86 (2006.01); C07K 14/47 (2006.01); A61K 38/04 (2006.01); C07K 7/08 (2006.01); A61K 38/10 (2006.01); C07K 14/00 (2006.01); C12N 15/62 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 38/04 (2013.01); A61K 38/10 (2013.01); A61K 38/16 (2013.01); C07K 7/08 (2013.01); C07K 14/00 (2013.01); C07K 14/4702 (2013.01); C07K 14/4703 (2013.01); C12N 15/62 (2013.01); C12N 15/86 (2013.01); C07K 2319/10 (2013.01); C12N 2310/14 (2013.01); C12N 2310/531 (2013.01);
Abstract

This document provides polypeptide inhibitors of Smad3 polypeptide activities. For example, methods and materials for using polypeptides (e.g., polypeptides designed to include both a cell penetrating amino acid sequence and an amino acid segment of a SH3 domain of a SNX9 polypeptide) to inhibit one or more Smad3 polypeptide activities are provided. This document also provides methods and materials for using RNA interference to treat a disease (e.g., a fibrotic disease) in a mammal (e.g., a human).

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