The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 08, 2020
Filed:
Sep. 15, 2016
Inserm (Institut National DE LA Sante ET DE LA Recherche Medicale), Paris, FR;
Univeriste DE Nantes, Nantes, FR;
Universite D'angers, Paris, FR;
Centre National DE LA Recherche Scientifique (Cnrs), Paris, FR;
Centre Hospitalier Universitaire DE Nantes, Nantes, FR;
Erwan Mortier, Nantes, FR;
Dihia Meghnem, Nantes, FR;
Sebastien Morisseau, Nantes, FR;
Yannick Jacques, Nantes, FR;
Insitut National de la Sante et de la Recherche Medicale (INSERM), Paris, FR;
Universite de Nantes, Nantes, FR;
Universite d'Angers, Paris, FR;
Centre National de la Recherche Scientifique, Paris, FR;
Centre Hospitalier Universitaire de Nantes, Nantes, FR;
Abstract
The present invention relates to specific interleukin-15 (IL-15) antagonist polypeptides and uses thereof for the treatment of inflammatory and auto-immune diseases. In particular, the present invention relates to a specific interleukin-15 (IL-15) antagonist polypeptide comprising i) a IL15-Ralpha sushi-containing polypeptide comprising an amino acid sequence having at least 80% of identity with the amino acid sequence of SEQ ID NO:1 ii) a linker and iii) an IL-polypeptide comprising the amino acid sequence having at least at least 80% of identity with the amino acid sequence of SEQ ID NO:4 provided that the glutamine (Q) residue at position 108 is mutated.