The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 08, 2020
Filed:
Jul. 08, 2015
Applicant:
Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA (US);
Inventors:
Linda M. Bradley, La Jolla, CA (US);
Roberto Tinoco, La Jolla, CA (US);
Assignee:
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, La Jolla, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 39/002 (2006.01); A61K 45/00 (2006.01); C07K 16/28 (2006.01); C07K 14/705 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2854 (2013.01); C07K 14/70596 (2013.01); C07K 16/2896 (2013.01); A61K 48/00 (2013.01); A61K 2039/505 (2013.01); C07K 2317/76 (2013.01);
Abstract
The present invention relates to the seminal discovery that P-selectin glycoprotein ligand-1 (PSGL-1) modulates the immune system and immune responses. Specifically, the present invention provides PSGL-1 agonists and antagonists which increase the survival of multifunctional T cells and viral clearance. The present invention further provides methods of treating infectious diseases, cancer and immune and inflammatory diseases and disorders using a PSGL-1 modulator.